Logopharm in the press

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Scientific publications

2019
High-Resolution Complexome Profiling by Cryoslicing BN-MS Analysis. Müller CS, Bildl W, Klugbauer N, Haupt A, Fakler B, Schulte U. J. Vis. Exp. 2019; (152), e60096.
https://doi.org/10.3791/60096
An ER Assembly Line of AMPA-Receptors Controls Excitatory Neurotransmission and Its Plasticity. Schwenk J, Boudkkazi S, Kocylowski MK, Brechet A, Zolles G, Bus T, Costa K, Kollewe A, Jordan J, Bank J, Bildl W, Sprengel R, Kulik A, Roeper J, Schulte U, Fakler B. Neuron 2019; S0896-6273(19)30739-1.
https://doi.org/10.1016/j.neuron.2019.08.033
2017
Neuroplastin and Basigin Are Essential Auxiliary Subunits of Plasma Membrane Ca2+-ATPases and Key Regulators of Ca2+ Clearance. Schmidt N, Kollewe A, Constantin CE, Henrich S, Ritzau-Jost A, Bildl W, Saalbach A, Hallermann S, Kulik A, Fakler B, Schulte U. Neuron 2017; 96;1–12. PubMed 29056295
The two-pore channel TPC1 is required for efficient protein processing through early and recycling endosomes. Castonguay J, Orth JHC, Müller T, Sleman F, Grimm C, Wahl-Schott C, Biel M, Mallmann RT, Bildl W, Schulte U, Klugbauer N. Sci Rep 2017; 7(1):10038. PubMed 28855648
AMPA-receptor specific biogenesis complexes control synaptic transmission and intellectual ability. Brechet A, Buchert R, Schwenk J, Boudkkazi S, Zolles G, Siquier-Pernet K, Schaber I, Bildl W, Saadi A, Bole-Feysot C, Nitschke P, Reis A, Sticht H, Al-Sanna'a N, Rolfs A, Kulik A, Schulte U, Colleaux L, Abou Jamra R, Fakler B. Nat Commun 2017; 114(22):5707-5712. PubMed 28675162
Identification of Cav2-PKCβ and Cav2-NOS1 complexes as entities for ultrafast electrochemical coupling. Constantin CE, Müller CS, Leitner MG, Bildl W, Schulte U, Oliver D, Fakler B. Proc Natl Acad Sci USA 2017; 114(22):5707-5712. PubMed 28507132
Depolarization causes the formation of a ternary complex between GlialCAM, MLC1 and ClC-2 in astrocytes: implications in megalencephalic leukoencephalopathy. Sirisi S, Elorza-Vidal X, Arnedo T, Armand-Ugón M, Callejo G, Capdevila-Nortes X, López-Hernández T, Schulte U, Barrallo-Gimeno A, Nunes V, Gasull X, Estévez R. Hum Mol Genet 2017; 26(13):2436-2450. PubMed 28398517
2016
CD13/aminopeptidase N is a negative regulator of mast cell activation. Zotz JS, Wölbing F, Lassnig C, Kauffmann M, Schulte U, Kolb A, Whitelaw B, Müller M, Biedermann T, Huber M. FASEB J 2016; 30(6):2225-35. PubMed 26936360
Modular composition and dynamics of native GABAB receptors identified by high-resolution proteomics. Schwenk J, Pérez-Garci E, Schneider A, Kollewe A, Gauthier-Kemper A, Fritzius T, Raveh A, Dinamarca MC, Hanuschkin A, Bildl W, Klingauf J, Gassmann M, Schulte U, Bettler B, Fakler B. Nat Neurosci 2016; 19(2):233-42. PubMed 26691831
2015
Cryo-slicing Blue Native-Mass Spectrometry (csBN-MS), a Novel Technology for High Resolution Complexome Profiling. Müller CS, Bildl W, Haupt A, Ellenrieder L, Becker T, Hunte C, Fakler B, Schulte U. Mol Cell Proteomics 2015; 15(2):669-81. PubMed 26598645
2014
Regional diversity and developmental dynamics of the AMPA-receptor proteome in the mammalian brain. Schwenk J, Baehrens D, Haupt A, Bildl W, Boudkkazi S, Roeper J, Fakler B, Schulte U. Neuron 2014; 84(1):41-54. PubMed 25242221
Identification of N-terminal protein acetylation and arginine methylation of the voltage-gated sodium channel in end-stage heart failure human heart. Beltran-Alvarez P, Tarradas A, Chiva C, Pérez-Serra A, Batlle M, Pérez-Villa F, Schulte U, Sabidó E, Brugada R, Pagans S. J Mol Cell Cardiol 2014; 76:126-129. PubMed 25172307
Auxiliary GABAB Receptor Subunits Uncouple G Protein βγ Subunits from Effector Channels to Induce Desensitization. Turecek R, Schwenk J, Fritzius T, Ivankova K, Zolles G, Adelfinger L, Jacquier V, Besseyrias V, Gassmann M, Schulte U, Fakler B, Bettler B. Neuron 2014; 82(5):1032-1044. PubMed 24836506
2013
Otoferlin couples to clathrin-mediated endocytosis in mature cochlear inner hair cells. Duncker SV, Franz C, Kuhn S, Schulte U, Campanelli D, Brandt N, Hirt B, Fakler B, Blin N, Ruth P, Engel J, Marcotti W, Zimmermann U, Knipper M. J Neurosci 2013; 33(22):9508-19. PubMed 23719817
2012
High-resolution proteomics unravel architecture and molecular diversity of native AMPA receptor complexes. Schwenk J, Harmel N, Brechet A, Zolles G, Berkefeld H, Müller CS, Bildl W, Baehrens D, Hüber B, Kulik A, Klöcker N, Schulte U, Fakler B. Neuron 2012; 74(4):621-33. PubMed 22632720
GlialCAM, a protein defective in a leukodystrophy, serves as a ClC-2 Cl(−) channel auxiliary subunit. Jeworutzki E, López-Hernández T, Capdevila-Nortes X, Sirisi S, Bengtsson L, Montolio M, Zifarelli G, Arnedo T, Müller CS, Schulte U, Nunes V, Martínez A, Jentsch TJ, Gasull X, Pusch M, Estévez R. Neuron 2012; 73(5):951-61. PubMed 22405205
2011
Extending The Dynamic Range Of Label-Free Mass Spectrometric Quantification Of Affinity Purifications. Bildl W, Haupt A, Mueller CS, Biniossek ML, Thumfart JO, Hueber B, Fakler B, Schulte U. Mol Cell Proteomics 2012; 11(2):M111.007955. Epub 2011 Nov 8. PubMed 22067099
Mutant GlialCAM causes megalencephalic leukoencephalopathy with subcortical cysts, benign familial macrocephaly, and macrocephaly with retardation and autism. López-Hernández T, Ridder MC, Montolio M, Capdevila-Nortes X, Polder E, Sirisi S, Duarri A, Schulte U, Fakler B, Nunes V, Scheper GC, Martínez A, Estévez R, van der Knaap MS. Am J Hum Genet 2011; 88(4):422-32. PubMed 21419380
Ion channels and their molecular environments - Glimpses and insights from functional proteomics. Schulte U, Müller C, Fakler B. Semin Cell Dev Biol. 2011; 22(2):132-44. PubMed 20934526
2010
Feature Article: Quantitative proteomics of the Cav2 channel nano-environments in the mammalian brain. Müller CS, Haupt A, Bildl W, Schindler J, Knaus HG, Meissner M, Rammner B, Striessnig J, Flockerzi V, Fakler B, Schulte U. Proc Natl Acad Sci USA 2010; 107(34):14950-7. PubMed 20668236
Ca2+-Activated K+ Channels: From Protein Complexes to Function. Berkefeld, H., Fakler, B., Schulte, U. Physiological Reviews 2010; 90(4):1437-59. PubMed 20959620
Native GABA(B) receptors are heteromultimers with a family of auxiliary subunits. Schwenk J, Metz M, Zolles G, Turecek R, Fritzius T, Bildl W, Tarusawa E, Kulik A, Unger A, Ivankova K, Seddik R, Tiao JY, Rajalu M, Trojanova J, Rohde V, Gassmann M, Schulte U, Fakler B, Bettler B. Nature 2010; 465(7295):231–5. PubMed 20400944
Polycystin-1 and -2 Dosage Regulates Pressure Sensing. Sharif-Naeini R, Folgering JHA, Bichet D, Duprat F, Lauritzen I, Arhatte M, Jodar M, Dedman A, Chatelain FC, Schulte U, Retailleau K, Loufrani L, Patel A, Sachs F, Delmas P, Peters DJM, Honore E. Cell 2009; 139(3):587–96. PubMed 19879844
2009
Association with the auxiliary subunit PEX5R/Trip8b controls responsiveness of HCN channels to cAMP and adrenergic stimulation. Zolles G, Wenzel D, Bildl W, Schulte U, Hofmann A, Müller C, Thumfart JO, Pfeifer A, Fleischmann BK, Fakler B, Klöcker N. Neuron 2009; 62(6):814-25. PubMed 19555650
Functional proteomics identify cornichon proteins as auxiliary subunits of AMPA receptors. Schwenk J, Harmel N, Zolles G, Bildl W, Kulik A, Heimrich B, Chisaka O, Jonas P, Schulte U, Fakler B, Klöcker N. Science 2009; 323(5919):1313-9. PubMed 19265014
2008
Profiling the phospho-status of the BKca channel a subunit in rat brain reveals unexpected patterns and complexity. Yan J, Olsen JV, Park KS, Li W, Bildl W, Schulte U, Aldrich RW, Fakler B, Trimmer JS. Mol Cell Proteomics 2008; 7(11):2188-98. PubMed 18573811
Extracellular loop C of NPC1L1 is important for binding to ezetimibe. Weinglass AB, Kohler M, Schulte U, Liu J, Nketiah EO, Thomas A, Schmalhofer W, Williams B, Bildl W, McMasters DR, Dai K, Beers L, McCann ME, Kaczorowski GJ, Garcia ML. Proc Natl Acad Sci USA 2008; 105(32):11140-5. PubMed 18682566
Protein-protein interactions and subunit composition of ion channels. Schulte U. CNS Neurol Disord Drug Targets 2008; 7(2):172-86. PubMed 18537645
2006
BKCa-Cav channel complexes mediate rapid and localized Ca2+-activated K+ signaling. Berkefeld H, Sailer CA, Bildl W, Rohde V, Thumfart JO, Eble S, Klugbauer N, Reisinger E, Bischofberger J, Oliver D, Knaus HG, Schulte U, Fakler B. Science 2006; 314(5799):615-20. PubMed 17068255
The epilepsy-linked Lgi1 protein assembles into presynaptic Kv1 channels and inhibits inactivation by Kvbeta1. Schulte U, Thumfart JO, Klöcker N, Sailer CA, Bildl W, Biniossek M, Dehn D, Deller T, Eble S, Abbass K, Wangler T, Knaus HG, Fakler B. Neuron 2006; 49(5):697-706. PubMed 16504945
2004
Protein kinase CK2 is coassembled with small conductance Ca(2+)-activated K+ channels and regulates channel gating. Bildl W, Strassmaier T, Thurm H, Andersen J, Eble S, Oliver D, Knipper M, Mann M, Schulte U, Adelman JP, Fakler B. Neuron 2004; 43(6): 847-58. PubMed 15363395