Logopharm in the press

• "Complex issues relating to membranes"

  BioPro portal | Jul 11, 2010 | English (German version)

• "From protein complexes to networks"

  BioPro portal | Oct 17, 2008 | English (German version)

• "Membrane Protein Challenge"

  Chemische Rundschau magazine | Sep 12, 2008 | English

Editorials, campaigns, application notes

• "Proteomics: taking on protein complexes"

  Editorial | Nature Methods Vol.13 No.9 2016 | English

• "Protein Complexes – Challenges and Opportunities for Drug Discovery"

  White Paper | Next Generation Pharmaceuticals Europe/USA 2008 | English

• "Omes and omics"

  Interview | Next Generation Pharmaceuticals Europe (285) 2008 | English

• Target R&D Services

  Advertisement | 2011 | English

Scientific publications

2019

High-Resolution Complexome Profiling by Cryoslicing BN-MS Analysis. Müller CS, Bildl W, Klugbauer N, Haupt A, Fakler B, Schulte U. J. Vis. Exp. 2019; (152), e60096.
https://doi.org/10.3791/60096

An ER Assembly Line of AMPA-Receptors Controls Excitatory Neurotransmission and Its Plasticity. Schwenk J, Boudkkazi S, Kocylowski MK, Brechet A, Zolles G, Bus T, Costa K, Kollewe A, Jordan J, Bank J, Bildl W, Sprengel R, Kulik A, Roeper J, Schulte U, Fakler B. Neuron 2019; S0896-6273(19)30739-1.
https://doi.org/10.1016/j.neuron.2019.08.033

2017

Neuroplastin and Basigin Are Essential Auxiliary Subunits of Plasma Membrane Ca2+-ATPases and Key Regulators of Ca2+ Clearance. Schmidt N, Kollewe A, Constantin CE, Henrich S, Ritzau-Jost A, Bildl W, Saalbach A, Hallermann S, Kulik A, Fakler B, Schulte U. Neuron 2017; 96;1–12. PubMed 29056295

The two-pore channel TPC1 is required for efficient protein processing through early and recycling endosomes. Castonguay J, Orth JHC, Müller T, Sleman F, Grimm C, Wahl-Schott C, Biel M, Mallmann RT, Bildl W, Schulte U, Klugbauer N. Sci Rep 2017; 7(1):10038. PubMed 28855648

AMPA-receptor specific biogenesis complexes control synaptic transmission and intellectual ability. Brechet A, Buchert R, Schwenk J, Boudkkazi S, Zolles G, Siquier-Pernet K, Schaber I, Bildl W, Saadi A, Bole-Feysot C, Nitschke P, Reis A, Sticht H, Al-Sanna'a N, Rolfs A, Kulik A, Schulte U, Colleaux L, Abou Jamra R, Fakler B. Nat Commun 2017; 114(22):5707-5712. PubMed 28675162

Identification of Cav2-PKCβ and Cav2-NOS1 complexes as entities for ultrafast electrochemical coupling. Constantin CE, Müller CS, Leitner MG, Bildl W, Schulte U, Oliver D, Fakler B. Proc Natl Acad Sci USA 2017; 114(22):5707-5712. PubMed 28507132

Depolarization causes the formation of a ternary complex between GlialCAM, MLC1 and ClC-2 in astrocytes: implications in megalencephalic leukoencephalopathy. Sirisi S, Elorza-Vidal X, Arnedo T, Armand-Ugón M, Callejo G, Capdevila-Nortes X, López-Hernández T, Schulte U, Barrallo-Gimeno A, Nunes V, Gasull X, Estévez R. Hum Mol Genet 2017; 26(13):2436-2450. PubMed 28398517

2016

CD13/aminopeptidase N is a negative regulator of mast cell activation. Zotz JS, Wölbing F, Lassnig C, Kauffmann M, Schulte U, Kolb A, Whitelaw B, Müller M, Biedermann T, Huber M. FASEB J 2016; 30(6):2225-35. PubMed 26936360

Modular composition and dynamics of native GABAB receptors identified by high-resolution proteomics. Schwenk J, Pérez-Garci E, Schneider A, Kollewe A, Gauthier-Kemper A, Fritzius T, Raveh A, Dinamarca MC, Hanuschkin A, Bildl W, Klingauf J, Gassmann M, Schulte U, Bettler B, Fakler B. Nat Neurosci 2016; 19(2):233-42. PubMed 26691831

2015

Cryo-slicing Blue Native-Mass Spectrometry (csBN-MS), a Novel Technology for High Resolution Complexome Profiling. Müller CS, Bildl W, Haupt A, Ellenrieder L, Becker T, Hunte C, Fakler B, Schulte U. Mol Cell Proteomics 2015; 15(2):669-81. PubMed 26598645

2014

Regional diversity and developmental dynamics of the AMPA-receptor proteome in the mammalian brain. Schwenk J, Baehrens D, Haupt A, Bildl W, Boudkkazi S, Roeper J, Fakler B, Schulte U. Neuron 2014; 84(1):41-54. PubMed 25242221

Identification of N-terminal protein acetylation and arginine methylation of the voltage-gated sodium channel in end-stage heart failure human heart. Beltran-Alvarez P, Tarradas A, Chiva C, Pérez-Serra A, Batlle M, Pérez-Villa F, Schulte U, Sabidó E, Brugada R, Pagans S. J Mol Cell Cardiol 2014; 76:126-129. PubMed 25172307

Auxiliary GABAB Receptor Subunits Uncouple G Protein βγ Subunits from Effector Channels to Induce Desensitization. Turecek R, Schwenk J, Fritzius T, Ivankova K, Zolles G, Adelfinger L, Jacquier V, Besseyrias V, Gassmann M, Schulte U, Fakler B, Bettler B. Neuron 2014; 82(5):1032-1044. PubMed 24836506

2013

Otoferlin couples to clathrin-mediated endocytosis in mature cochlear inner hair cells. Duncker SV, Franz C, Kuhn S, Schulte U, Campanelli D, Brandt N, Hirt B, Fakler B, Blin N, Ruth P, Engel J, Marcotti W, Zimmermann U, Knipper M. J Neurosci 2013; 33(22):9508-19. PubMed 23719817

2012

High-resolution proteomics unravel architecture and molecular diversity of native AMPA receptor complexes. Schwenk J, Harmel N, Brechet A, Zolles G, Berkefeld H, Müller CS, Bildl W, Baehrens D, Hüber B, Kulik A, Klöcker N, Schulte U, Fakler B. Neuron 2012; 74(4):621-33. PubMed 22632720

GlialCAM, a protein defective in a leukodystrophy, serves as a ClC-2 Cl(−) channel auxiliary subunit. Jeworutzki E, López-Hernández T, Capdevila-Nortes X, Sirisi S, Bengtsson L, Montolio M, Zifarelli G, Arnedo T, Müller CS, Schulte U, Nunes V, Martínez A, Jentsch TJ, Gasull X, Pusch M, Estévez R. Neuron 2012; 73(5):951-61. PubMed 22405205

2011

Extending The Dynamic Range Of Label-Free Mass Spectrometric Quantification Of Affinity Purifications. Bildl W, Haupt A, Mueller CS, Biniossek ML, Thumfart JO, Hueber B, Fakler B, Schulte U. Mol Cell Proteomics 2012; 11(2):M111.007955. Epub 2011 Nov 8. PubMed 22067099

Mutant GlialCAM causes megalencephalic leukoencephalopathy with subcortical cysts, benign familial macrocephaly, and macrocephaly with retardation and autism. López-Hernández T, Ridder MC, Montolio M, Capdevila-Nortes X, Polder E, Sirisi S, Duarri A, Schulte U, Fakler B, Nunes V, Scheper GC, Martínez A, Estévez R, van der Knaap MS. Am J Hum Genet 2011; 88(4):422-32. PubMed 21419380

Ion channels and their molecular environments - Glimpses and insights from functional proteomics. Schulte U, Müller C, Fakler B. Semin Cell Dev Biol. 2011; 22(2):132-44. PubMed 20934526

2010

Feature Article: Quantitative proteomics of the Cav2 channel nano-environments in the mammalian brain. Müller CS, Haupt A, Bildl W, Schindler J, Knaus HG, Meissner M, Rammner B, Striessnig J, Flockerzi V, Fakler B, Schulte U. Proc Natl Acad Sci USA 2010; 107(34):14950-7. PubMed 20668236

Ca2+-Activated K+ Channels: From Protein Complexes to Function. Berkefeld, H., Fakler, B., Schulte, U. Physiological Reviews 2010; 90(4):1437-59. PubMed 20959620

Native GABA(B) receptors are heteromultimers with a family of auxiliary subunits. Schwenk J, Metz M, Zolles G, Turecek R, Fritzius T, Bildl W, Tarusawa E, Kulik A, Unger A, Ivankova K, Seddik R, Tiao JY, Rajalu M, Trojanova J, Rohde V, Gassmann M, Schulte U, Fakler B, Bettler B. Nature 2010; 465(7295):231–5. PubMed 20400944

Polycystin-1 and -2 Dosage Regulates Pressure Sensing. Sharif-Naeini R, Folgering JHA, Bichet D, Duprat F, Lauritzen I, Arhatte M, Jodar M, Dedman A, Chatelain FC, Schulte U, Retailleau K, Loufrani L, Patel A, Sachs F, Delmas P, Peters DJM, Honore E. Cell 2009; 139(3):587–96. PubMed 19879844

2009

Association with the auxiliary subunit PEX5R/Trip8b controls responsiveness of HCN channels to cAMP and adrenergic stimulation. Zolles G, Wenzel D, Bildl W, Schulte U, Hofmann A, Müller C, Thumfart JO, Pfeifer A, Fleischmann BK, Fakler B, Klöcker N. Neuron 2009; 62(6):814-25. PubMed 19555650

Functional proteomics identify cornichon proteins as auxiliary subunits of AMPA receptors. Schwenk J, Harmel N, Zolles G, Bildl W, Kulik A, Heimrich B, Chisaka O, Jonas P, Schulte U, Fakler B, Klöcker N. Science 2009; 323(5919):1313-9. PubMed 19265014

2008

Profiling the phospho-status of the BKca channel a subunit in rat brain reveals unexpected patterns and complexity. Yan J, Olsen JV, Park KS, Li W, Bildl W, Schulte U, Aldrich RW, Fakler B, Trimmer JS. Mol Cell Proteomics 2008; 7(11):2188-98. PubMed 18573811

Extracellular loop C of NPC1L1 is important for binding to ezetimibe. Weinglass AB, Kohler M, Schulte U, Liu J, Nketiah EO, Thomas A, Schmalhofer W, Williams B, Bildl W, McMasters DR, Dai K, Beers L, McCann ME, Kaczorowski GJ, Garcia ML. Proc Natl Acad Sci USA 2008; 105(32):11140-5. PubMed 18682566

Protein-protein interactions and subunit composition of ion channels. Schulte U. CNS Neurol Disord Drug Targets 2008; 7(2):172-86. PubMed 18537645

2006

BKCa-Cav channel complexes mediate rapid and localized Ca2+-activated K+ signaling. Berkefeld H, Sailer CA, Bildl W, Rohde V, Thumfart JO, Eble S, Klugbauer N, Reisinger E, Bischofberger J, Oliver D, Knaus HG, Schulte U, Fakler B. Science 2006; 314(5799):615-20. PubMed 17068255

The epilepsy-linked Lgi1 protein assembles into presynaptic Kv1 channels and inhibits inactivation by Kvbeta1. Schulte U, Thumfart JO, Klöcker N, Sailer CA, Bildl W, Biniossek M, Dehn D, Deller T, Eble S, Abbass K, Wangler T, Knaus HG, Fakler B. Neuron 2006; 49(5):697-706. PubMed 16504945

2004

Protein kinase CK2 is coassembled with small conductance Ca(2+)-activated K+ channels and regulates channel gating. Bildl W, Strassmaier T, Thurm H, Andersen J, Eble S, Oliver D, Knipper M, Mann M, Schulte U, Adelman JP, Fakler B. Neuron 2004; 43(6): 847-58. PubMed 15363395